Euphorbia hirta, Triphala combination, Withania somnifera, Glycyrrhiza glabra and Zingiber officinale. This formulation has been selected for our work as it principally contains flavonoids, carotenoids, catechins and many other chemical constituents that are known for their anti-inflammatory activity. The presence of these chemicals initiated us to perform the study. Therefore, the present study was undertaken to screen and evaluate the anti-inflammatory activity of this herbal combination.Acute toxicity studies were carried out and the herbal extract did not show any mortality or sign of toxicity in experimental rats.Carrageenan was shown to induce a general inflammatory response by causing an increased production of pro-inflammatory mediators such as TNF-a, and IL’s. Administration of methanolic extract 100mg (P<0.05) and 200mg (P<0.001) significantly inhibited the development of the swelling as compared to the induced (Carrageenan) group. From the above investigation it can be concluded that methanolic extract (200mg) of the herbal extract showed reduction in edema and is comparable to standard Ibuprofen.
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